Renal reserve: a functional view of glomerular filtration rate.

Bosch JP. Division of Renal Diseases and Hypertension, George Washington University, Washington, DC 20037, USA.
Semin Nephrol 1995 Sep;15(5):381-385

The hyperfiltration theory challenged the view that glomerular filtration rate is a fixed function as well as that there is a good correlation between GFR and renal parenchymal damage. Glomerular filtration rate is a dynamic parameter that is diet-dependent and can be altered by hemodynamic maneuvers. Therefore, it is not a good indicator of renal lesion. The renal reserve is an indicator of the workload per nephron and may be a useful parameter to assess the progression of renal disease in the presence of dietary or pharmacological intervention.